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The Problem

 

Medication non-adherence is a major driver of preventable illness, hospitalizations, and healthcare costs. It occurs in two key forms:

 

Misuse and Abuse of Prescription Medications

 

In 2020, millions in the U.S. misused prescription drugs:

• 9.3 million misused opioids

• 6.2 million misused sedatives/tranquilizers

• 5.1 million misused stimulants

 

This results in an estimated $72.5 billion annually in healthcare costs, with opioid abusers incurring 8.7 times higher costs than non-abusers.

 

Underuse in Chronic Disease Treatment

 

Up to 50% of patients don't take medications as prescribed, contributing to:

• 10% of hospitalizations

• $100 billion in excess healthcare costs annually

 

Impact on Clinical Trials

 

Non-adherence also undermines drug development. Fewer than 50% of trial participants fully adhere to medication regimens, increasing costs and contributing to the 80% failure rate of clinical trials.

 

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© 2025 Compliance Strategies LLC

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